台湾北部具有头孢菌素类药物低敏性的耐多药淋病奈瑟菌分离株中携带镶嵌青霉素结合蛋白 2 的多态性特征及其传播。
Characteristics and dissemination of mosaic penicillin-binding protein 2-harboring multidrug-resistant Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility in northern Taiwan.
机构信息
Research and Diagnostic Center, Centers for Disease Control, No. 161 Kun-Yang Street, Taipei, Taiwan.
出版信息
Antimicrob Agents Chemother. 2010 Nov;54(11):4893-5. doi: 10.1128/AAC.00482-10. Epub 2010 Aug 23.
Abstract
Among 254 Neisseria gonorrhoeae isolates from a sexually transmitted infection (STI) clinic in northern Taiwan, 69 isolates were found to contain the mosaic penA (MA) gene and were associated with elevated cefixime and ceftriaxone MICs. Most of these MA gene-harboring isolates were also resistant to penicillin (71.4%) and ciprofloxacin (100%) and were from men who have sex with men (MSM) or from bisexual men (81.2%). Three major sequence types (ST835, ST2180, and ST2253) constituted 55.7% of these isolates. The major sequence types harboring the mosaic penA gene may represent major sexual networks responsible for the emergence/introduction and the spread of the multidrug-resistant clones in Taiwan.
摘要
在台湾北部一家性传播感染（STI）诊所的 254 株淋病奈瑟菌分离株中，发现 69 株含有镶嵌 penA（MA）基因，与头孢克肟和头孢曲松 MIC 值升高有关。这些携带 MA 基因的分离株大多数也对青霉素（71.4%）和环丙沙星（100%）具有耐药性，并且来自男男性接触者（MSM）或双性恋男性（81.2%）。三个主要序列型（ST835、ST2180 和 ST2253）占这些分离株的 55.7%。携带镶嵌 penA 基因的主要序列型可能代表主要的性传播网络，负责出现/引入和耐药克隆在台湾的传播。
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