Li A M, Cheng M Y
Department of Paediatrics, Hong Kong University, Queen Mary Hospital.
J Paediatr Child Health. 1990 Dec;26(6):339-42. doi: 10.1111/j.1440-1754.1990.tb02448.x.
A study was conducted on 447 healthy high school students of southern Chinese descent to determine the prevalence of anaemia and thalassaemia. Haematological data and serum ferritin levels were determined on all venous blood samples. Haemoglobin (Hb) electrophoretic study was conducted on 43 students who had anaemia (Hb less than 12 g/dL), and/or mean corpuscular volume (MCV) less than 80 fL. They were re-assessed after 1 month of oral iron therapy. Three girls had definite iron deficient anaemia (less than 1%). Thirty-nine students had either alpha, or beta-thalassaemia, only seven of whom showed anaemia. Since the overwhelming majority of both the thalassaemic students (38 of 39) and the participants (429 of 447) were of Cantonese extraction (native of Guangdong province), the overall incidence of 8.8% (alpha-thalassaemia 5.4%, beta-thalassaemia 3.4%) reflected the high frequency of the thalassaemia gene among this group of southern Chinese. MCV measurement, rather than Hb, was more useful in its detection.
对447名中国南方血统的健康高中生进行了一项研究，以确定贫血和地中海贫血的患病率。对所有静脉血样本测定血液学数据和血清铁蛋白水平。对43名贫血（血红蛋白低于12g/dL）和/或平均红细胞体积（MCV）低于80fL的学生进行了血红蛋白（Hb）电泳研究。口服铁剂治疗1个月后对他们进行了重新评估。三名女孩患有明确的缺铁性贫血（不到1%）。39名学生患有α或β地中海贫血，其中只有7人表现出贫血。由于绝大多数地中海贫血学生（39人中的38人）和参与者（447人中的429人）都是广东血统（广东省本地人），8.8%的总体发病率（α地中海贫血5.4%，β地中海贫血3.4%）反映了这组中国南方人群中地中海贫血基因的高频率。MCV测量而非Hb测量在其检测中更有用。
