[来自莫斯科的急性中风患者的磷酸二酯酶4D（PDE4D）基因多态性]
[Phosphodiesterase 4D (PDE4D) gene polymorphism in patients with acute stroke from Moscow].
作者信息
Bondarenko E A, Tupitsyna T V, Slominskiĭ P A, Shetova I M, Shamalov N A, Botsina A Iu, Skvortsova V I, Limborskaia S A
出版信息
Genetika. 2010 Jun;46(6):861-4.
Two PDE4D gene polymorphisms [SNP41 (rs152312 and SNP87 (rs 2910829)] were studied in patients with acute stroke (n = 577) and in control sample (n = 270). Significant differences in the genotype and allele frequency distribution were found between these samples for polymorphism SNP41. We showed that the AA and AG genotypes of SNP41 polymorphism were associated with higher risk of acute stroke development in the Moscow population (OR = 1.6). No association of SNP87 polymorphism with the disease was observed.
在577例急性中风患者和270例对照样本中研究了两种磷酸二酯酶4D（PDE4D）基因多态性[SNP41（rs152312）和SNP87（rs2910829）]。对于多态性SNP41，在这些样本之间发现基因型和等位基因频率分布存在显著差异。我们发现，在莫斯科人群中，SNP41多态性的AA和AG基因型与急性中风发生的较高风险相关（比值比=1.6）。未观察到SNP87多态性与该疾病有关联。
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