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[肝脏再生过程中血清卵磷脂-胆固醇酰基转移酶反应的特点]

[The characteristics of the lecithin-cholesterol-acyltransferase reaction in the blood serum during liver regeneration].

作者信息

Chirkin A A, Konevalova N Iu, Gidranovich L G

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1990(11):26-34.

PMID:2073530
Abstract

The rate of cholesterin ether formation in blood serum during the periods of rapid recovery of liver mass decreases after partial hepatectomy in rats. This effect is connected with the changes in quantity and composition of lecithin cholesterin acyltransferase (LCAT) as well the kinetic characteristics of lipoprotein of high density. This ferment was isolated from blood serum and purified in 28,500 times at different periods of liver regeneration. A conclusion concerning the presence of reverse dependence between the pronounced regeneration processes in liver and LCAT activity at high level of nonetherificated cholesterin in substrate has been drawn. Some recommendations for LCAT activity reducing processes in liver are given.

摘要

大鼠部分肝切除术后,在肝质量快速恢复期间,血清中胆固醇醚的形成速率降低。这种效应与卵磷脂胆固醇酰基转移酶(LCAT)的数量和组成变化以及高密度脂蛋白的动力学特征有关。在肝脏再生的不同时期,从血清中分离出这种酶并将其纯化了28500倍。得出了关于肝脏中明显的再生过程与底物中高含量非酯化胆固醇时LCAT活性之间存在反向依赖性的结论。给出了一些降低肝脏中LCAT活性过程的建议。

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