King's College London, Department of Addictions, Institute of Psychiatry, London, UK.
Addiction. 2011 Jan;106(1):154-61. doi: 10.1111/j.1360-0443.2010.03130.x. Epub 2010 Aug 23.
Mephedrone (4-methylmethcathinone) is a novel synthetic stimulant drug that has recently become popular in the United Kingdom and elsewhere in Europe. It has a short history of human consumption and little is known about its prevalence and pattern of use. This study aimed to obtain preliminary data on its use and effects among dance drug users in the United Kingdom.
Cross-sectional anonymous online survey of mephedrone recruited as part of larger study exploring patterns of drug use among those associated with the dance music scene. Setting UK-based dance music and clubbing website.
A total of 947 ever users of mephedrone recruited as part of a wider study on dance drug use patterns.
Assessment of demographics, ever and current drug use and patterns and selected effects following use of mephedrone.
A total of 947 (41.3%) of 2295 participants reported ever having used mephedrone. Mephedrone was the sixth most frequently used drug in the last month after tobacco, alcohol, cannabis, cocaine and 3,4-methylenedioxymethamphetamine (MDMA). Users were typically younger (P < 0.001) and male (P < 0.01); 15.1% reported using weekly or more frequently; 49.5% reported using between 0.5 and 1 g during a typical session; 69.5% reported that intranasal use was the most common route of use. Intranasal use was associated with increased abuse liability; 54.6% of those who have also used cocaine reported that the quality of the high obtained with mephedrone was better, with those using intranasally being significantly more likely than those who took the drug orally to report that mephedrone was more addictive (P < 0.02) and more risky (P < 0.02) than cocaine. Route of use was unrelated to any stimulant-related adverse effect apart from palpitations (P < 0.005).
Mephedrone appears to be used primarily intranasally and to have comparable abuse potential to cocaine, with more than half those who use both reporting that mephedrone gives a better quality high.
甲卡西酮（4-甲基甲卡西酮）是一种新型合成兴奋剂，最近在英国和欧洲其他地区流行。人类对它的使用历史较短，对其流行程度和使用模式知之甚少。本研究旨在获得有关其在英国舞蹈药物使用者中的使用和效果的初步数据。
作为一项更大规模研究的一部分，对甲卡西酮进行了横断面匿名在线调查，该研究旨在探索与舞蹈音乐场景相关人群的药物使用模式。
英国的一个舞蹈音乐和俱乐部网站。
共有 947 名曾使用过甲卡西酮的参与者，他们是更广泛的舞蹈药物使用模式研究的一部分。
评估人口统计学、过去和现在的药物使用情况以及使用甲卡西酮后的选择效果。
在 2295 名参与者中，共有 947 名（41.3%）报告曾使用过甲卡西酮。甲卡西酮是过去一个月中仅次于烟草、酒精、大麻、可卡因和 3,4-亚甲二氧基甲基苯丙胺（MDMA）的第六大最常使用药物。使用者通常更年轻（P<0.001）且为男性（P<0.01）；15.1%报告每周或更频繁使用；49.5%报告在一次典型的使用中使用 0.5 到 1 克；69.5%报告鼻腔内使用是最常见的使用途径。鼻腔内使用与滥用倾向增加有关；54.6%曾使用可卡因的人报告说，使用甲卡西酮获得的快感质量更好，鼻腔内使用者比口服使用者更有可能报告说，甲卡西酮比可卡因更具成瘾性（P<0.02）和风险更高（P<0.02）。使用途径与除心悸（P<0.005）以外的任何与兴奋剂相关的不良影响无关。
甲卡西酮似乎主要通过鼻腔内使用，其滥用潜力与可卡因相当，超过一半同时使用两者的人报告说，甲卡西酮产生的快感质量更好。
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