Lind L J, Mushlin P S, Schnitman P A
Harvard School of Dental Medicine.
J Oral Implantol. 1990;16(2):106-13.
The optimal method of providing safe and effective sedation for outpatients undergoing lengthy dental operations is unclear. We provided monitored anesthesia care (conscious sedation) for 102 consecutive dental implant procedures, using intravenous midazolam and fentanyl as primary pharmacologic agents. Midazolam was administered by multiple, intermittent injection or via continuous infusion. The dose of midazolam required for the induction of sedation ranged from 3.4 +/- 1.6 mg to 4.0 +/- 2.0 mg. Maintenance of adequate sedation required a mean midazolam administration rate of 4.0 +/- 2.1 mg/h to 5.1 +/- 2.1 mg/h, and a mean fentanyl administration rate of 54 +/- 29 mcg/h to 60 +/- 27 mcg/h. Continuous monitoring allowed for rapid detection and treatment of 40 separate hemodynamic and respiratory problems. There was no evidence of patient injury, and all patients returned home on the day of surgery. A post-operative telephone survey revealed that 65% of patients had complete amnesia for operative events, 96% were satisfied with monitored anesthesia care, and 94% would desire a similar anesthetic technique for future procedures.
对于接受长时间牙科手术的门诊患者,提供安全有效的镇静的最佳方法尚不清楚。我们连续为102例牙科种植手术提供了监护麻醉(清醒镇静),使用静脉注射咪达唑仑和芬太尼作为主要药物。咪达唑仑通过多次间歇注射或持续输注给药。诱导镇静所需的咪达唑仑剂量范围为3.4±1.6毫克至4.0±2.0毫克。维持足够的镇静需要咪达唑仑的平均给药速率为4.0±2.1毫克/小时至5.1±2.1毫克/小时,芬太尼的平均给药速率为54±29微克/小时至60±27微克/小时。持续监测能够快速检测和处理40起不同的血流动力学和呼吸问题。没有患者受伤的证据,所有患者均在手术当天回家。术后电话调查显示,65%的患者对手术事件完全失忆,96%的患者对监护麻醉满意,94%的患者希望在未来手术中采用类似的麻醉技术。