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[肿瘤凝集素学——临床应用现状与展望]

[Tumor lectinology--status and perspectives of clinical application].

作者信息

Gabius H J, Gabius S

机构信息

Max-Planck-Institut für experimentelle Medizin, Abteilung Chemie, Göttingen.

出版信息

Naturwissenschaften. 1990 Nov;77(11):505-14. doi: 10.1007/BF01139261.

Abstract

A detailed knowledge of the mechanisms of molecular recognition is a prerequisite to rationally improved diagnostic and therapeutic procedures in diseases. In addition to sequences of amino acids, carbohydrate structures apparently store biological information that is thought to be relevant for physiologically important processes. Such ligands, namely the carbohydrate part of cellular glycoconjugates, can be recognized by specific endogenous binding proteins like lectins. If their presence can be reliably ascertained and correlated to the clinical course of the disease, e.g. in oncology, lectinology may help to define a yet undisclosed role for this class of proteins in tumor progression and spread.

摘要

深入了解分子识别机制是合理改进疾病诊断和治疗程序的前提条件。除氨基酸序列外,碳水化合物结构显然也储存着被认为与生理重要过程相关的生物信息。此类配体,即细胞糖缀合物的碳水化合物部分,可被凝集素等特定内源性结合蛋白识别。如果能够可靠地确定它们的存在并将其与疾病的临床进程相关联,例如在肿瘤学领域,凝集素学可能有助于明确这类蛋白质在肿瘤进展和扩散中尚未被揭示的作用。

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