Kageyama Y, Kusuyama H, Lu Y W, Nagashima H, Kase H, Araki S, Hobo M, Itoh H, Nakamura K, Katoh M
Department of Urology, Saitama Medical School.
Hinyokika Kiyo. 1990 Dec;36(12):1403-7.
Seventeen patients with renal stones and 17 patients with ureteral stones were treated using the newly developed piezoelectric shock wave lithotripter, THERASONIC. To determine the effect of shock wave on renal function, urinary N-acetyl-beta-D-glucosaminidase (NAG) activity, urinary beta 2 microglobulin (BMG) concentration, serum BMG concentration and creatinine clearance (Ccr) were measured. Urinary NAG activity and urinary BMG concentration in renal stone patients were significantly elevated immediately after the treatment and returned to the pretreatment value within 24 hours. Neither serum BMG nor Ccr showed significant change in any of the patients. Therefore, we conclude that the renal tubular damage, which is transient and subtle, is the effect of shock wave lithotripsy using THERASONIC machine.
使用新开发的压电冲击波碎石机THERASONIC对17例肾结石患者和17例输尿管结石患者进行了治疗。为了确定冲击波对肾功能的影响，检测了尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）活性、尿β2微球蛋白（BMG）浓度、血清BMG浓度和肌酐清除率（Ccr）。肾结石患者治疗后尿NAG活性和尿BMG浓度立即显著升高，并在24小时内恢复到治疗前水平。所有患者的血清BMG和Ccr均未显示出显著变化。因此，我们得出结论，使用THERASONIC机器进行冲击波碎石术会造成短暂而细微的肾小管损伤。
