采用地高辛特异性抗体片段及血浆置换疗法治疗一名肾衰竭患者的地高辛中毒。

Treatment of digoxin intoxication in a renal failure patient with digoxin-specific antibody fragments and plasmapheresis.

作者信息

Rabetoy G M, Price C A, Findlay J W, Sailstad J M

机构信息

Department of Internal Medicine (Nephrology Division), Naval Hospital, San Diego, Calif.

出版信息

Am J Nephrol. 1990;10(6):518-21. doi: 10.1159/000168179.

DOI:10.1159/000168179

PMID:2075910

Abstract

A patient with renal failure due to myeloma kidney and coincident digitalis intoxication due to prescribed daily digoxin administration was treated with digoxin-specific antibody fragments and plasmapheresis. Rapid response to therapy was noted, removal of digoxin-antidigoxin antibody complexes was confirmed, and prevention of delayed rebound toxicity was documented. We suggest that this is the therapy of choice in similar individuals.

摘要

一名因骨髓瘤肾病导致肾衰竭且因每日服用地高辛而同时发生洋地黄中毒的患者，接受了地高辛特异性抗体片段和血浆置换治疗。观察到对治疗的快速反应，证实了地高辛-抗地高辛抗体复合物的清除，并记录了对延迟性反跳毒性的预防。我们建议这是类似患者的首选治疗方法。