Kloeden P E, Rössler R, Rössler O E
Medical Policlinic, University of Tübingen, FRG.
Gerontology. 1990;36(5-6):314-22. doi: 10.1159/000213216.
It is proposed that a centralized clock controlling ageing is located in the pineal gland with the calcification process occurring there providing a highly accurate bio-inorganic timing mechanism and the secreted melatonin carrying a signal to all cells in the organism. An explicit programme of data gathering and experiments suitable for the falsification of the proposal, which is consistent with presently known anatomical and physiological facts, is presented. The underlying motivation comes from evolutionary biology and the invariance, that is the allometry, of life expectancy curves.
有人提出，控制衰老的中央时钟位于松果体，那里发生的钙化过程提供了一种高度精确的生物无机计时机制，而分泌的褪黑素则向生物体中的所有细胞传递信号。本文提出了一个明确的数据收集和实验计划，该计划适用于对这一与目前已知的解剖学和生理学事实相符的提议进行证伪。其潜在动机来自进化生物学以及预期寿命曲线的不变性，即异速生长。
