Bobryshev P Iu, Bagaeva T R, Filaretova L P
Ross Fiziol Zh Im I M Sechenova. 2010 Jun;96(6):609-20.
The study was designed to investigate whether glucocorticoid hormones participate in gastroprotective effects of ischemic preconditioning in rats with normal and deficient prostaglandin production. To estimate the role of glucocorticoids adrenalectomy followed by appropriate corticosterone replacement and inhibition of corticosterone synthesis by metyrapone were used. Prostaglandin synthesis was inhibited by indomethacin. In control rats gastric ischemic preconditioning (a 0.5 h ischemia-reperfusion) induced plasma corticosterone rise and attenuated gastric injury caused by 3.5 h ischemia-reperfusion. The gastroprotective effect of ischemic preconditioning was prevented by adrenalectomy as well as metyrapone pretreatment in both groups, in the rats with normal and deficient prostaglandin production. Acute corticosterone replacement to adrenalectomized rats during ischemic preconditioning restored the protective effect of ischemic preconditioning on the gastric mucosa even in the rats with inhibited prostaglandin synthesis. Thus, the glucocorticoid hormones were shown to contribute to gastroprotective effect of ischemic preconditioning in the rats with normal and deficient prostaglandin production.
本研究旨在探讨糖皮质激素是否参与正常及前列腺素生成不足的大鼠缺血预处理的胃保护作用。为评估糖皮质激素的作用，采用了肾上腺切除术并给予适当的皮质酮替代，以及用甲吡酮抑制皮质酮合成。用吲哚美辛抑制前列腺素合成。在对照大鼠中，胃缺血预处理（0.5小时缺血-再灌注）导致血浆皮质酮升高，并减轻了3.5小时缺血-再灌注引起的胃损伤。在前列腺素生成正常和不足的两组大鼠中，肾上腺切除术以及甲吡酮预处理均阻止了缺血预处理的胃保护作用。在缺血预处理期间，对肾上腺切除的大鼠进行急性皮质酮替代，即使在前列腺素合成受抑制的大鼠中，也恢复了缺血预处理对胃黏膜的保护作用。因此，已表明糖皮质激素有助于正常及前列腺素生成不足的大鼠缺血预处理的胃保护作用。
