Rush University Medical Center, Department of Immunology and Microbiology, 1735 W Harrison Street, Cohn Building Chicago, Illinois 60612, USA.
Adv Exp Med Biol. 2010;684:69-78. doi: 10.1007/978-1-4419-6451-9_6.
Immunological memory is considered the hallmark of adaptive, or acquired, immunity. That ability of our immune system to recognize and respond to those pathogens we have encountered before not only typifies acquired immunity but has provided the basis for the most notable of medical interventions: vaccination. Yet, as much as we now know about this process, we are still on the cusp of fully understanding how memory T cells develop, how they are maintained and the importance of memory T-cell heterogeneity. In this review we will primarily focus on our understanding of CD8 T-cell memory generated during acute infections and how precursor frequency influences their development and functional attributes.
免疫记忆被认为是适应性或获得性免疫的标志。我们的免疫系统能够识别和应对以前遇到过的病原体的这种能力不仅是获得性免疫的典型特征，而且为最显著的医学干预措施提供了基础：疫苗接种。然而，尽管我们现在对这个过程有了很多了解，但我们仍处于完全理解记忆 T 细胞如何发育、如何维持以及记忆 T 细胞异质性的重要性的边缘。在这篇综述中，我们将主要关注我们对急性感染期间产生的 CD8 T 细胞记忆的理解，以及前体细胞频率如何影响其发育和功能特性。
