肉毒梭菌C2毒素和产气荚膜梭菌iota毒素对肌动蛋白的ADP-核糖基化作用的表征
Characterization of the ADP-ribosylation of actin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.
作者信息
Aktories K, Geipel U, Wille M, Just I
机构信息
Rudolf-Buchheim Institut für Pharmakologie, Universität Giessen.
出版信息
J Physiol (Paris). 1990;84(4):262-6.
PMID:2079662
Abstract
Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin belong to a novel family of actin ADP-ribosylating toxins. ADP-ribosylation of actin inhibits actin polymerization and G-actin-associated ATPase activity. The ADP-form of actin is ADP-ribosylated at a higher rate than actin with bound ATP. ADP-ribosylation of actin is reversible, a reaction, which is accompanied by reconstitution of actin ATPase activity.
摘要
肉毒梭菌C2毒素和产气荚膜梭菌iota毒素属于肌动蛋白ADP核糖基化毒素的一个新家族。肌动蛋白的ADP核糖基化抑制肌动蛋白聚合和G-肌动蛋白相关的ATP酶活性。与结合ATP的肌动蛋白相比，ADP形式的肌动蛋白以更高的速率被ADP核糖基化。肌动蛋白的ADP核糖基化是可逆的，该反应伴随着肌动蛋白ATP酶活性的重建。
相似文献
1
Characterization of the ADP-ribosylation of actin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.
J Physiol (Paris). 1990;84(4):262-6.
2
ADP-ribosylation of skeletal muscle and non-muscle actin by Clostridium perfringens iota toxin.
Eur J Biochem. 1988 Jan 15;171(1-2):225-9. doi: 10.1111/j.1432-1033.1988.tb13780.x.
3
ADP-ribosylation of actin isoforms by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.
Eur J Biochem. 1990 Nov 26;194(1):237-41. doi: 10.1111/j.1432-1033.1990.tb19448.x.
4
Adenine nucleotides regulate ADP-ribosylation of membrane-bound actin and actin-binding to membranes.
Eur J Cell Biol. 1994 Feb;63(1):3-9.
5
ADP-ribosylation of Drosophila indirect-flight-muscle actin and arthrin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.
Biochem J. 1993 Apr 15;291 ( Pt 2)(Pt 2):409-12. doi: 10.1042/bj2910409.
6
De-ADP-ribosylation actin by Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin.
Eur J Biochem. 1990 Sep 24;192(3):723-7. doi: 10.1111/j.1432-1033.1990.tb19282.x.
7
Botulinum C2 toxin ADP-ribosylates actin.
Nature. 1986;322(6077):390-2. doi: 10.1038/322390a0.
8
ADP-ribosylation of gelsolin-actin complexes by clostridial toxins.
J Biol Chem. 1992 Jan 5;267(1):50-5.
9
Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177.
FEBS Lett. 1987 Dec 10;225(1-2):48-52. doi: 10.1016/0014-5793(87)81129-8.
10
Inhibition of cytochalasin D-stimulated G-actin ATPase by ADP-ribosylation with Clostridium perfringens iota toxin.
Biochem J. 1990 Mar 1;266(2):335-9. doi: 10.1042/bj2660335.
引用本文的文献
1
Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins.
Mol Cell Biochem. 1994 Sep;138(1-2):167-76. doi: 10.1007/BF00928459.
Zotero 插件