性别对健康人体葡萄糖利用率的影响：一项正电子发射断层扫描研究。

Effect of gender on glucose utilization rates in healthy humans: a positron emission tomography study.

作者信息

Miura S A, Schapiro M B, Grady C L, Kumar A, Salerno J A, Kozachuk W E, Wagner E, Rapoport S I, Horwitz B

机构信息

Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892.

出版信息

J Neurosci Res. 1990 Dec;27(4):500-4. doi: 10.1002/jnr.490270410.

DOI:10.1002/jnr.490270410

PMID:2079712

Abstract

Positron emission tomography (PET) was used with 18fluorodeoxyglucose to see if gender differences in resting cerebral glucose utilization could be detected. Thirty-two healthy subjects (15 women and 17 men; age range: 21-38 yr) were examined using a high-resolution PET scanner to determine the regional cerebral metabolic rate for glucose (CMRglc) in 65 gray matter regions of interest. Whole brain CMRglc did not differ significantly between the two genders, nor did any of the regional CMRglc values. Only 1 of 65 ratios of regional-to-whole brain CMRglc differed significantly between men and women, which is consistent with chance. These results indicate that there are no differences in resting regional cerebral glucose utilization between young men and women.

摘要

正电子发射断层扫描（PET）结合18氟脱氧葡萄糖用于观察是否能检测到静息状态下大脑葡萄糖利用的性别差异。使用高分辨率PET扫描仪对32名健康受试者（15名女性和17名男性；年龄范围：21 - 38岁）进行检查，以确定65个灰质感兴趣区域的局部脑葡萄糖代谢率（CMRglc）。全脑CMRglc在两性之间无显著差异，任何局部CMRglc值也无差异。在65个局部与全脑CMRglc的比值中，只有1个在男性和女性之间存在显著差异，这与随机情况相符。这些结果表明，年轻男性和女性在静息状态下局部脑葡萄糖利用无差异。