与丙型肝炎病毒相关的皮肤疾病：事实与争议。

Skin diseases associated with hepatitis C virus: facts and controversies.

机构信息

Department of Endocrinological and Medical Sciences, University of Genoa, Genova, Italy.

出版信息

Clin Dermatol. 2010 Sep-Oct;28(5):489-96. doi: 10.1016/j.clindermatol.2010.03.004.

DOI:10.1016/j.clindermatol.2010.03.004

PMID:20797507

Abstract

Hepatitis C virus (HCV) is a common infectious agent and may induce several systemic disorders like mixed cryoglobulinemia. In the geographic areas where HCV infection is hyperendemic, HCV is the predominant etiologic factor for porphyria cutanea tarda and lichen planus. Vasculitides and autoimmune disorders, such as sicca syndrome, are probably often related to the virus. Interferon-a2b, which is largely used in the treatment of HCV-positive patients, may induce cell-mediated autoimmune side effects. Dermatologists may help to identify those patients timely.

摘要

丙型肝炎病毒（HCV）是一种常见的传染性病原体，可能会引起多种全身性疾病，如混合性冷球蛋白血症。在 HCV 感染高度流行的地理区域，HCV 是迟发性皮肤卟啉病和扁平苔藓的主要病因。血管炎和自身免疫性疾病，如干燥综合征，可能与病毒有关。干扰素-α2b 广泛用于治疗 HCV 阳性患者，可能会引起细胞介导的自身免疫副作用。皮肤科医生可能有助于及时识别这些患者。