Universidad Autónoma de Guerrero (UAGRO), Taxco, Guerrero, Mexico.
Occup Environ Med. 2010 Sep;67(9):620-4. doi: 10.1136/oem.2009.047928.
To investigate biomarkers of cytogenotoxicity in women exposed to mercury in a mining area. Mercury has been associated with cytogenotoxicity in human and animal models but has not been considered carcinogenic in humans, even though genotoxic effects following exposure to inorganic mercury compounds have been observed.
A cross-sectional study and micronucleus assay in uroepithelial cells were performed in 104 women (12-84 years of age). First urine void samples were taken to determine creatinine-adjusted mercury levels in urine (HgUCr), to isolate cells and to quantify cytogenetic damage.
The geometric average level for HgUCr was 4.9 microg/g (range, 0.4-85). In the generalised linear model, after controlling for other co-variables, we observed that for each 10 microg/g increase in HgUCr, the OR of developing a genotoxic effect was 2.37 (95% CI 1.79 to 2.84), while for cytotoxic damage in uroepithelial cells the OR was 1.34 (95% CI 1.10 to 1.79). These results suggest a possible association between cytogenotoxicity and HgUCr.
Living in a mining area with exposure to inorganic mercury and having higher mercury levels in urine increased the risk of developing uroepithelial cytogenotoxicity.
研究暴露于矿区汞环境中的女性细胞遗传毒性的生物标志物。汞已在人类和动物模型中与细胞遗传毒性相关联，但尚未被认为对人类具有致癌性，尽管已经观察到接触无机汞化合物后会产生遗传毒性效应。
在 104 名女性（12-84 岁）中进行了横断面研究和尿路上皮细胞微核试验。首先采集首次排尿样本，以确定尿肌酐调整后的汞水平（HgUCr），分离细胞并量化细胞遗传损伤。
HgUCr 的几何平均值为 4.9 微克/克（范围为 0.4-85）。在广义线性模型中，在控制其他协变量后，我们观察到 HgUCr 每增加 10 微克/克，发生遗传毒性效应的比值比为 2.37（95%置信区间 1.79 至 2.84），而尿路上皮细胞的细胞毒性损伤的比值比为 1.34（95%置信区间 1.10 至 1.79）。这些结果表明细胞遗传毒性与 HgUCr 之间可能存在关联。
生活在存在无机汞暴露的矿区并使尿液中的汞含量升高会增加发生尿路上皮细胞遗传毒性的风险。
