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儿童人工耳蜗植入后脑膜炎和急性中耳炎的预防和治疗。

Prevention and treatment of meningitis and acute otitis media in children with cochlear implants.

机构信息

Division of Pediatric Infectious Diseases, Steven and Alexandra Cohen Children's Medical Center of New York, North Shore-Long Island Jewish Health System, New Hyde Park, New York 11040, USA.

出版信息

Otol Neurotol. 2010 Oct;31(8):1331-3. doi: 10.1097/MAO.0b013e3181f2f074.

Abstract

OBJECTIVE

To provide recommendations for 1) prevention of acute otitis media and meningitis via immunization and 2) antimicrobial therapy of acute otitis media and meningitis in children with cochlear implants.

DATA SOURCES

Literature review and policy statement from the American Academy of Pediatrics.

CONCLUSION

  1. Children who are candidates for cochlear implants or have received cochlear implants should receive all-age appropriate vaccinations, including indicated doses of 13-valent pneumococcal conjugate vaccine, Haemophilus influenzae type b conjugate vaccine, and influenza vaccine. A supplemental dose of 13-valent pneumococcal conjugate vaccine is indicated for children who have received indicated doses of 7-valent pneumococcal vaccine, but have not received 13-valent pneumococcal conjugate vaccine. In addition, children 24 months and older should receive a single dose of 23-valent pneumococcal polysaccharide vaccine. 2) Acute otitis media in children with cochlear implants should be treated with an antimicrobial. During the first 2 months after implant, initial treatment of acute otitis media with a parenteral antimicrobial, e.g., cetriaxone, is indicated. High-dose amoxicillin or amoxicillin-clavulanate is an appropriate antimicrobial choice for empiric treatment of acute otitis media occurring 2 or more months after implant. In cases of meningitis occurring during the first 2 months after implantation, broad spectrum empiric antimicrobial therapy, e.g., meropenem and vancomycin, should be initiated pending the results of CSF culture. Empiric antimicrobial therapy with ceftriaxone and vancomycin is appropriate for cases of meningitis occurring 2 or more months after implant.
摘要

目的

提供 1)通过免疫接种预防急性中耳炎和脑膜炎,以及 2)对植入人工耳蜗的儿童的急性中耳炎和脑膜炎进行抗菌治疗的建议。

资料来源

美国儿科学会的文献回顾和政策声明。

结论

1)有植入人工耳蜗资格或已植入人工耳蜗的儿童应接种所有年龄段适用的疫苗,包括 13 价肺炎球菌结合疫苗、流感嗜血杆菌 b 型结合疫苗和流感疫苗的推荐剂量。已接种 7 价肺炎球菌疫苗且未接种 13 价肺炎球菌结合疫苗的儿童,应接种一剂 13 价肺炎球菌结合疫苗。此外,24 个月及以上的儿童应接种一剂 23 价肺炎球菌多糖疫苗。2)植入人工耳蜗的儿童急性中耳炎应使用抗菌药物治疗。在植入后 2 个月内,应使用头孢曲松等注射用抗菌药物进行急性中耳炎的初始治疗。对于植入后 2 个月或以上发生的急性中耳炎,高剂量阿莫西林或阿莫西林克拉维酸是经验性治疗的合适抗菌药物选择。在植入后 2 个月内发生脑膜炎的情况下,应在等待脑脊液培养结果的同时,开始使用广谱经验性抗菌治疗,如美罗培南和万古霉素。对于植入后 2 个月或以上发生的脑膜炎,头孢曲松和万古霉素的经验性抗菌治疗是合适的。

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