Department of Neuropsychiatry, Oita University Faculty of Medicine, Yufu City, Oita, Japan.
Psychopharmacology (Berl). 2011 Feb;213(2-3):633-8. doi: 10.1007/s00213-010-1999-0. Epub 2010 Aug 28.
Hyperthymic temperament is one of several premorbid temperaments putatively associated with bipolar disorder. Several reports suggest that depressive patients with hyperthymic temperament may belong to the proposed soft bipolar spectrum.
To investigate biological aspects of hyperthymic temperament, the present study examined daily activity, sleep time, central serotonergic function, and other relevant variables in relation to hyperthymic temperament in healthy subjects.
Fifty six healthy subjects were monitored via the actigraphy system to measure daily total activity, sleep time, and illuminance. A neuroendocrine challenge test was performed to estimate central serotonergic function.
Multiple regression analysis revealed that higher illuminance of daytime, greater fluctuation in sleep time, and lower central serotonergic function significantly and independently predicted hyperthymic temperament scores.
The present findings suggest that light, sleep, and serotonin are crucial factors in understanding hyperthymic temperament, which may be common to bipolar disorder.
欣快气质是几种被认为与双相情感障碍有关的前驱气质之一。有几项报告表明，具有欣快气质的抑郁患者可能属于所提出的软性双相谱。
为了研究欣快气质的生物学方面，本研究在健康受试者中检查了与欣快气质相关的日常活动、睡眠时间、中枢 5-羟色胺能功能和其他相关变量。
通过活动记录仪系统监测 56 名健康受试者，以测量日常总活动量、睡眠时间和光照度。进行神经内分泌挑战测试以估计中枢 5-羟色胺能功能。
多元回归分析显示，白天较高的光照度、睡眠时间波动较大以及中枢 5-羟色胺能功能较低，这些因素显著且独立地预测了欣快气质评分。
本研究结果表明，光、睡眠和 5-羟色胺是理解欣快气质的关键因素，这可能与双相情感障碍有关。
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