[一位联用锂盐和利培酮的分裂情感性障碍患者的紧张症困境]
[Catatonic dilemma in a schizoaffective patient with combined lithium-risperidone administration].
作者信息
Krähenmann Rainer, Küchenhoff Bernhard, Böker Heinz, Schick Matthis
机构信息
Psychiatrische Universitätsklinik Zürich, Klinik für Affektive Erkrankungen und Allgemeinpsychiatrie ZH Ost, Lenggstrasse 31, Postfach 1931, 8032 Zürich, Schweiz.
出版信息
Psychiatr Prax. 2010 Sep;37(6):306-9. doi: 10.1055/s-0030-1248498. Epub 2010 Aug 27.
OBJECTIVE
The case of a schizoaffective patient suffering from a malignant catatonic syndrome following combined lithium-risperidone therapy is explored.
METHOD
A case report and relevant deliberations regarding pathophysiology of the catatonic dilemma are discussed.
CONCLUSIONS
There are two critical transitions in the development of a malignant catatonic syndrome. Dopaminergic system and psychopharmacological factors are supposed to play a key role. However, other neurotransmitter systems and the individual predisposition must be considered.
目的
探讨一例精神分裂症伴情感障碍患者在锂盐与利培酮联合治疗后发生恶性紧张症综合征的病例。
方法
讨论了一例病例报告以及关于紧张症困境病理生理学的相关思考。
结论
恶性紧张症综合征的发展存在两个关键转变。多巴胺能系统和精神药理学因素被认为起关键作用。然而，其他神经递质系统和个体易感性也必须予以考虑。
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