Environmental Toxicology Center, Division of Research & Development, Korea Institute of Toxicology (KIT) , Yuseong, Daejon, Korea.
Nanotoxicology. 2011 Jun;5(2):208-14. doi: 10.3109/17435390.2010.508137. Epub 2010 Aug 31.
Silver nanoparticles (AgNPs) are increasingly used in various fields. However, little is known about the environmental effects of widespread use of products containing AgNPs. The objective of this study was to determine the ecotoxicity caused by AgNPs. The 48-h effective concentration 50 (EC(50)) values for Daphnia magna of suspensions of 60 nm and 300 nm AgNPs were 1.0 (95% confidence interval [CI] = 0.1-1.3) and 1.4 (95% CI = 0.3-2.1) μg Ag/l, respectively. The 96 h LC(50) values for Oryzias latipes of 60 nm and 300 nm AgNP suspensions were 28 (95% CI = 23-34) and 67 (95% CI = 45-108) μg Ag/l, respectively. To show that toxicity is caused only by Ag(+) and not by AgNPs, Ag(+) was adsorbed onto the synthesized sorbents packed in a column and D. magna was exposed to the column-passed-300 nm AgNP suspensions. There was no acute toxicity with the AgNP suspensions not containing Ag(+).
银纳米粒子（AgNPs）在各个领域的应用越来越广泛。然而，对于广泛使用含 AgNPs 产品所带来的环境影响知之甚少。本研究旨在确定 AgNPs 所产生的生态毒性。60nm 和 300nmAgNPs 悬浮液对大型溞（Daphnia magna）的 48 小时有效浓度 50（EC50）值分别为 1.0（95%置信区间[CI] = 0.1-1.3）和 1.4（95%CI = 0.3-2.1）μg Ag/L。60nm 和 300nmAgNP 悬浮液对斑马鱼（Oryzias latipes）的 96 小时半数致死浓度（LC50）值分别为 28（95%CI = 23-34）和 67（95%CI = 45-108）μg Ag/L。为了证明毒性仅由 Ag(+)引起，而不是由 AgNPs 引起，将 Ag(+)吸附到合成的吸附剂上，并将其填充在柱中，然后将大型溞暴露于经过柱处理的 300nmAgNP 悬浮液中。不含 Ag(+)的 AgNP 悬浮液没有急性毒性。
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