Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
Eur J Med Chem. 2010 Nov;45(11):4997-5005. doi: 10.1016/j.ejmech.2010.08.006. Epub 2010 Aug 12.
In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer complex was prepared and characterized by FTIR, solubility and in vitro drug release study. PETIM dendrimer was found to have significantly less toxicity in A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 days sub-acute toxicity measurement in mice showed no mortality, hematological, biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery.
在本研究中，我们尝试研究 G3-COOH 聚丙基亚胺（PETIM）树枝状大分子的急性和亚急性毒性概况，并将其用作模型药物酮洛芬的持续释放载体。通过傅里叶变换红外光谱（FTIR）、溶解度和体外药物释放研究对药物-树枝状大分子复合物进行了制备和表征。与聚酰胺-胺（PAMAM）树枝状大分子相比，发现 PETIM 树枝状大分子在 A541 细胞中的毒性明显降低。此外，在小鼠中进行的急性和 28 天亚急性毒性测量表明，高达 80mg/kg 剂量的 PETIM 树枝状大分子不会引起死亡、血液学、生化或组织病理学变化。研究结果表明，G3-COOH PETIM 树枝状大分子可用作安全有效的持续药物递送载体。
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