寻找慢性疼痛药物治疗的新策略。
Searching for new strategies for the pharmacological treatment of chronic pain.
作者信息
Salvemini Daniela
机构信息
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA.
出版信息
Mo Med. 2010 Jul-Aug;107(4):262-4.
Abstract
Chronic pain is poorly managed and represents a huge unmet medical need that affects humans globally. The traditional multifaceted drug regimens for controlling chronic pain are marginally effective, produce highly variable results and display for the most parts unacceptable side effects. Research efforts over the last decade have identified peroxynitrite (PN) as a critical signaling molecule in the development of pain. Targeting PN is a novel evidence-based approach to develop novel therapeutics for managing chronic pain.
摘要
慢性疼痛的治疗效果不佳，是一个巨大的未被满足的医学需求，在全球范围内影响着人类。传统的用于控制慢性疼痛的多方面药物治疗方案效果甚微，结果差异很大，而且在大多数情况下会产生不可接受的副作用。过去十年的研究工作已确定过氧亚硝酸盐（PN）是疼痛发展中的关键信号分子。针对PN是开发治疗慢性疼痛新疗法的一种基于新证据的方法。
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