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药物洗脱球囊治疗药物洗脱支架再发性支架内再狭窄

[Drug-eluting balloon in the treatment of a recurrent in-stent restenosis of drug-eluting stent].

作者信息

Merkely Béla, Jambrik Zoltán

机构信息

Semmelweis Egyetem, Altalános Orvostudományi Kar Kardiológiai Központ, Budapest.

出版信息

Orv Hetil. 2010 Sep 12;151(37):1509-14. doi: 10.1556/OH.2010.28934.

Abstract

Although medical treatment of atherosclerotic processes as a cause of the coronary artery disease has its own fundamental role, percutaneous coronary interventions showed an impressing development due to the intensive innovation. The use of stents increased the success rate of percutaneous coronary interventions, but in-stent restenosis appeared as a new complication. Drug eluting stents are dedicated to decrease the frequency of intima proliferation facilitating in-stent restenosis. After implantation of a drug-eluting stent, in-stent restenosis occurs in less than 10% of the patients. In spite of the improving results, in-stent restenosis of a drug-eluting stent has been remained unsolved. Besides the biodegradable stents/polymers, drug-eluting balloon may indicate the future technology. In this paper a very exciting, educative case is presented with a summary of the literature of drug-eluting balloon technique.

摘要

尽管针对作为冠状动脉疾病病因的动脉粥样硬化进程进行药物治疗有其根本作用,但由于创新的不断推进,经皮冠状动脉介入治疗取得了令人瞩目的发展。支架的使用提高了经皮冠状动脉介入治疗的成功率,但支架内再狭窄成为一种新的并发症。药物洗脱支架致力于降低内膜增生频率,从而促进支架内再狭窄。植入药物洗脱支架后,不到10%的患者会发生支架内再狭窄。尽管结果有所改善,但药物洗脱支架的支架内再狭窄问题仍未得到解决。除了可生物降解支架/聚合物外,药物洗脱球囊可能代表着未来的技术。本文介绍了一个非常令人兴奋且有教育意义的病例,并对药物洗脱球囊技术的文献进行了总结。

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