西班牙人群中 2p15 基因间单核苷酸多态性 rs10865331 与强直性脊柱炎的关联。
Association of the intergenic single-nucleotide polymorphism rs10865331 (2p15) with ankylosing spondylitis in a Spanish population.
机构信息
Laboratory of Rheumatology, Puerta de Hierro University Hospital, C/Joaquín Rodrigo 2, Majadahonda 28222, Madrid, Spain.
出版信息
J Rheumatol. 2010 Nov;37(11):2345-7. doi: 10.3899/jrheum.100211. Epub 2010 Sep 1.
OBJECTIVE
A recent genome-wide association study has identified 2 single-nucleotide polymorphisms (SNP) associated with ankylosing spondylitis (AS), rs10865331 (2p15) and rs2242944 (21q22). We assessed the association of these SNP with AS in a Spanish population.
METHODS
Four hundred fifty-six patients with AS fulfilling the modified New York Criteria and 300 healthy donors were analyzed. Result. SNP rs10865331 (allele A: p = 0.039; genotype: p = 0.016) was significantly associated with AS, while no association was found for rs2242944.
CONCLUSION
This is the first study that replicates in an independent cohort the association of the intergenic SNP rs10865331 with susceptibility to AS.
目的
最近的全基因组关联研究鉴定出与强直性脊柱炎（AS）相关的 2 个单核苷酸多态性（SNP），rs10865331（2p15）和 rs2242944（21q22）。我们评估了这些 SNP 与西班牙人群中 AS 的关联性。
方法
分析了符合改良纽约标准的 456 例 AS 患者和 300 名健康供体。结果：SNP rs10865331（等位基因 A：p=0.039；基因型：p=0.016）与 AS 显著相关，而 rs2242944 则没有关联。
结论
这是首次在独立队列中复制研究发现的基因间 SNP rs10865331 与 AS 易感性相关的研究。
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