来自于美国野生动物和媒介以及家犬的克氏锥虫分离株在 ICR 株小鼠和 SD 株大鼠中的感染性、致病性和毒力。
Infectivity, pathogenicity, and virulence of Trypanosoma cruzi Isolates from sylvatic animals and vectors, and domestic dogs from the United States in ICR strain mice and SD strain rats.
机构信息
Department of Infectious Diseases, College of Veterinary Medicine, Southeastern Cooperative Wildlife Disease Study, Department of Population Health, and D. B. Warnell School of Forestry and Natural Resources, The University of Georgia, Athens, Georgia, USA.
出版信息
Am J Trop Med Hyg. 2010 Sep;83(3):519-22. doi: 10.4269/ajtmh.2010.09-0663.
Abstract
Trypanosoma cruzi, the causative agent of Chagas disease, is widespread in the southern United States. In addition to detection in numerous wildlife host species, cases have been diagnosed in domestic dogs and humans. In the current investigation, groups of laboratory mice [Crl:CD1 (ICR)] were inoculated with one of 18 United States T. cruzi isolates obtained from a wide host range to elucidate their infectivity, pathogenicity, and virulence. In addition, laboratory rats (SD strain) were inoculated with four isolates. Mice and rats were susceptible to infection with all strains, but no morbidity or mortality was noted, which indicates that these T. cruzi isolates from the United States had low virulence for laboratory mice and rats.
摘要
克氏锥虫，恰加斯病的病原体，广泛分布于美国南部。除了在众多野生动物宿主物种中检测到外，还在家养狗和人类中诊断出病例。在目前的调查中，一组实验室小鼠 [Crl:CD1 (ICR)] 接种了从广泛宿主中获得的 18 株美国 T. cruzi 分离株之一，以阐明其感染性、致病性和毒力。此外，实验室大鼠（SD 株）接种了 4 株分离株。小鼠和大鼠均易感染所有分离株，但未观察到发病率或死亡率，这表明这些来自美国的 T. cruzi 分离株对实验室小鼠和大鼠的毒力较低。
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