S100A1：骨骼肌中兰尼碱受体1（RYR1）、钙离子释放及收缩性的一种生理调节因子。聚焦于“S100A1促进骨骼肌中动作电位引发的钙释放通量及力量产生” 。 - Suppr

S100A1: a physiological modulator of RYR1, Ca2+ release, and contractility in skeletal muscle. Focus on "S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle".

作者信息

Heiny Judith A

出版信息

Am J Physiol Cell Physiol. 2010 Nov;299(5):C882-4. doi: 10.1152/ajpcell.00349.2010. Epub 2010 Sep 1.

DOI:10.1152/ajpcell.00349.2010

PMID:20810914

Abstract

摘要

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S100A1: a physiological modulator of RYR1, Ca2+ release, and contractility in skeletal muscle. Focus on "S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle".

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S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle.

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Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1.

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S100A1 and calmodulin compete for the same binding site on ryanodine receptor.

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Loss of S100A1 expression leads to Ca release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1.

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引用本文的文献

Loss of S100A1 expression leads to Ca release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1.

Physiol Rep. 2018 Aug;6(15):e13822. doi: 10.14814/phy2.13822.

Functional classification of skeletal muscle networks. II. Applications to pathophysiology.

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S100A1: a physiological modulator of RYR1, Ca2+ release, and contractility in skeletal muscle. Focus on "S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle".

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S100A1: a physiological modulator of RYR1, Ca2+ release, and contractility in skeletal muscle. Focus on "S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle".

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