一名浆细胞白血病患者在使用粒细胞集落刺激因子动员进行自体干细胞移植时发生脾破裂。

Splenic rupture in a plasma cell leukemia, mobilized with G-CSF for autologous stem cell transplant.

作者信息

Funes Consuelo, Garcia-Candel Faustino, Majado Maria Juliana, González-García Consuelo, Bas Agueda, Salido Eduardo, Moraleda Jose M, Morales Alfonso

机构信息

Servicio de Hematología, Hospital V Arrixaca, Murcia, Spain.

出版信息

J Clin Apher. 2010;25(4):223-5. doi: 10.1002/jca.20233.

DOI:10.1002/jca.20233

PMID:20818717

Abstract

Splenic rupture (SR) is a rare adverse event observed in patients treated with G-CSF as a peripheral hematopoietic stem cell (PHSC) mobilizing agent, mostly in myeloma multiple and amiloidosis; to date, to our knowledge, it has not been previously described in plasma-cell leukemia (PCL). We report a case of a woman with PCL, who presented a SR after PHSC mobilization with Cyclophosphamide+G-CSF. The spleen removed showed hematopoietic foci and amiloid material. In the course of a second mobilization, 2 months after, the patient died from sepsis. We considered it important to report this case, in order to keep in mind the possibility of SR in patients with malignant gammopathy.

摘要

脾破裂（SR）是使用粒细胞集落刺激因子（G-CSF）作为外周造血干细胞（PHSC）动员剂治疗的患者中观察到的一种罕见不良事件，多见于多发性骨髓瘤和淀粉样变性患者；据我们所知，迄今为止，浆细胞白血病（PCL）患者中尚未有过相关描述。我们报告了1例PCL女性患者，该患者在接受环磷酰胺+G-CSF进行PHSC动员后出现脾破裂。切除的脾脏显示有造血灶和淀粉样物质。在2个月后的第二次动员过程中，患者死于败血症。我们认为报告该病例很重要，以便牢记恶性丙种球蛋白病患者发生脾破裂的可能性。