Kaidar-Person Orit, Nasrallah Haitam, Haim Nissim, Dann Eldad J, Bar-Sela Gil
Division of Oncology, Rambam Health Care Campus and Faculty of Medicine, Technion-Israel Institute of Technology, POB 9602, Haifa 31096, Israel.
J Gastrointest Cancer. 2011 Sep;42(3):123-6. doi: 10.1007/s12029-010-9204-6.
Malignancy is often associated with hematological disorders, but rarely is the diagnosis of malignancy secondary to the diagnosis of microangiopathic hemolytic anemia and thrombocytopenia.
We report hereby two patients with metastatic gastric carcinoma presenting with microangiopathic hemolytic anemia and thrombocytopenia. Despite chemotherapy and repeated plasmapheresis in one patient, both patients succumbed shortly after the diagnosis of cancer was made.
A review of the literature regarding microangiopathic hemolytic anemia in cancer patients is discussed. In patients suffering from microangiopathic hemolytic anemia and thrombocytopenia, malignancy should be considered as a possible cause. Early diagnosis of malignancy may be critical for determining the patient's prognosis and potentially avoiding unnecessary overtreatment.
恶性肿瘤常与血液系统疾病相关，但因微血管病性溶血性贫血和血小板减少症而继发恶性肿瘤诊断的情况很少见。
我们在此报告两例转移性胃癌患者，他们表现为微血管病性溶血性贫血和血小板减少症。尽管其中一名患者接受了化疗和反复的血浆置换，但两名患者在癌症诊断后不久均死亡。
本文讨论了关于癌症患者微血管病性溶血性贫血的文献综述。对于患有微血管病性溶血性贫血和血小板减少症的患者，应考虑恶性肿瘤作为可能的病因。早期诊断恶性肿瘤对于确定患者的预后并可能避免不必要的过度治疗可能至关重要。
