Kroll J S, Loynds B, Brophy L N, Moxon E R
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
Mol Microbiol. 1990 Nov;4(11):1853-62. doi: 10.1111/j.1365-2958.1990.tb02034.x.
The nucleotide sequence of a 5.1 kb region in the Haemophilus influenzae type b capsulation locus has been determined and found to contain four open reading frames: bexD, bexC, bexB, and bexA. Comparison of the deduced products of bexC, bexB, and bexA to known proteins, and TnphoA mutagenesis, suggests that they form components of an ATP-driven polysaccharide export apparatus. Furthermore, close sequence similarity between BexA and BexB and products of the kpsT and kpsM genes at the Escherichia coli K5 capsulation locus (Smith et al., 1990--accompanying paper) suggests that capsulation genes in these organisms may have a common ancestry.
已确定b型流感嗜血杆菌荚膜形成位点中一个5.1 kb区域的核苷酸序列，发现其包含四个开放阅读框：bexD、bexC、bexB和bexA。将bexC、bexB和bexA推导的产物与已知蛋白质进行比较以及TnphoA诱变表明，它们构成了一个由ATP驱动的多糖输出装置的组件。此外，BexA和BexB与大肠杆菌K5荚膜形成位点的kpsT和kpsM基因产物之间的紧密序列相似性（Smith等人，1990年——附随论文）表明，这些生物体中的荚膜形成基因可能有共同的祖先。
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