苯并三唑-1-基磺酰叠氮化物用于重氮转移和叠氮酰基苯并三唑的制备。

Benzotriazol-1-yl-sulfonyl azide for diazotransfer and preparation of azidoacylbenzotriazoles.

机构信息

Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA.

出版信息

J Org Chem. 2010 Oct 1;75(19):6532-9. doi: 10.1021/jo101296s.

DOI:10.1021/jo101296s

PMID:20825153

Abstract

Benzotriazol-1-yl-sulfonyl azide, a new crystalline, stable, and easily available diazotransfer reagent provides N-(α-azidoacyl)benzotriazoles convenient for N-, O-, C- and S-acylations. The efficient syntheses of various amides, azido protected peptides, esters, ketones and thioesters is reported together with a wide range of azides (including α-azido acids from α- amino acids in partially aqueous conditions) and diazo compounds.

摘要

苯并三唑-1-基磺酰叠氮化物，一种新型结晶、稳定、易得的重氮转移试剂，提供了方便的 N-(α-叠氮酰基)苯并三唑，可用于 N-、O-、C-和 S-酰化。报道了各种酰胺、叠氮保护的肽、酯、酮和硫酯的高效合成方法，以及广泛的叠氮化物（包括部分水条件下从α-氨基酸得到的α-叠氮酸）和重氮化合物。