Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
J Neuroimmunol. 2010 Dec 15;229(1-2):238-42. doi: 10.1016/j.jneuroim.2010.08.009. Epub 2010 Sep 9.
We investigated T cell immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS) and assessed cross-reactivity of the anti-EBV cellular response with brain antigens. We measured the proliferation, cytotoxicity, and number of interferon-γ secreting cells following stimulation with autologous EBV-infected lymphoblastoid cell lines (LCL) in MS patients and matched controls. There were no statistically significant differences for any of the measured responses, but there was a trend towards decreased proliferative responses in MS patients. There was no measured cross-reactivity between LCL and brain antigens. We conclude that the cellular immune response against EBV-infected cells is neither increased nor decreased in MS.
我们研究了多发性硬化症（MS）患者对 EBV 病毒（EBV）的 T 细胞免疫反应，并评估了抗 EBV 细胞反应与脑抗原的交叉反应性。我们通过用自体 EBV 感染的淋巴母细胞系（LCL）刺激，测量了 MS 患者和匹配对照者的增殖、细胞毒性和干扰素-γ分泌细胞的数量。任何测量的反应均无统计学显著差异，但 MS 患者的增殖反应呈下降趋势。在 LCL 和脑抗原之间未测量到交叉反应性。我们得出结论，MS 患者针对 EBV 感染细胞的细胞免疫反应既没有增加也没有减少。
