Biolatris Ltd, St John's Innovation Centre, Cowley Road, Cambridge CB4 0WS, UK.
J R Soc Interface. 2010 Dec 6;7 Suppl 6(Suppl 6):S783-7. doi: 10.1098/rsif.2010.0351.focus. Epub 2010 Sep 8.
Cells respond to their structural surrounding and within nanostructures exhibit unique proliferative and differentiation properties. The application of nanotechnologies to the field of regenerative medicine offers the potential to direct cell fate, target the delivery of cells and reduce immune rejection (via encapsulation), thereby supporting the development of regenerative medicines. The overall objective of any therapy is the delivery of the product not just into the clinic but also to patients on a routine basis. Such a goal typically requires a commercial vehicle and substantial levels of investment in scientific, clinical, regulatory and business expertise, resources, time and funding. Therefore, this paper focuses on some of the challenges facing this emerging industry, including investment by the venture capital community.
细胞会对其所处的结构环境做出响应,而纳米结构中则表现出独特的增殖和分化特性。将纳米技术应用于再生医学领域,有望对细胞命运进行定向控制,实现细胞的靶向投递,并减少免疫排斥(通过封装),从而为再生医学的发展提供支持。任何治疗的总体目标不仅是将产品递送至临床,而且还要常规地递送至患者。要实现这一目标,通常需要商业载体,并且需要在科学、临床、监管和商业专业知识、资源、时间和资金方面进行大量投资。因此,本文重点关注这一新兴产业所面临的一些挑战,包括风险投资界的投资。