[棉酚醛基衍生物的制备]
[Preparation of derivatives of the aldehydic functions of gossypol].
作者信息
Kunesch N, Barbier M P, Dalkafouki A, Poisson J E
机构信息
Laboratoire de Chimie des Substances thérapeutiques naturelles, UA CNRS n. 496, Centre d'Etudes pharmaceutiques, Châtenay-Malabry.
出版信息
Ann Pharm Fr. 1990;48(1):1-6.
Several new derivatives of the aldehydic functions of (+/-) gossypol are described: an hydrosoluble hydrazide resulting from the reaction with the Girard's reagent T and Schiff bases with polyamines. The condensation between the two aldehyde groups and cadaverine, putrescine or spermidine gives macrocyclic bridged products. A disubstituted non cyclic derivative is obtained with an excess of cadaverine. These products are of biological interest.
描述了几种（±）棉酚醛基的新衍生物：一种与吉拉德试剂T反应生成的水溶性酰肼以及与多胺形成的席夫碱。两个醛基与尸胺、腐胺或亚精胺之间的缩合反应生成大环桥连产物。用过量的尸胺可得到一种二取代的非环状衍生物。这些产物具有生物学意义。
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