Department of Cardiology, Haydarpaşa Numune Education and Research Hospital, Istanbul, Turkey.
Expert Rev Clin Immunol. 2010 Sep;6(5):777-88. doi: 10.1586/eci.10.47.
Inflammatory mediators, adhesion molecules of neutrophils and monocytes, have been shown to be increased in the plasma of patients presenting with acute coronary syndromes. Anaphylaxis is a systemic, immediate hypersensitivity reaction caused by rapid IgE-mediated release of mediators from mast cells and basophils. Kounis syndrome is the coincidental occurrence of these two distinct conditions accompanied by clinical and laboratory findings of angina pectoris caused by inflammatory mediators released during an allergic insult. Allergic angina can progress to acute myocardial infarction, which is termed 'allergic myocardial infarction'. There are several causes reported to be capable of inducing Kounis syndrome. These include a number of conditions, several drugs, foods and insect stings, among others. In this article, the clinical aspects, diagnosis, pathogenesis, incidence and epidemiology, related conditions and therapeutic management of this important syndrome are discussed.
在出现急性冠状动脉综合征的患者的血浆中，已经发现炎症介质、中性粒细胞和单核细胞的黏附分子增加。过敏反应是一种全身性的、即刻的超敏反应，由肥大细胞和嗜碱性粒细胞中 IgE 介导的介质快速释放引起。Kounis 综合征是这两种截然不同的情况同时发生，并伴有心绞痛的临床和实验室发现，这是由过敏反应期间释放的炎症介质引起的。过敏性心绞痛可进展为急性心肌梗死，称为“过敏性心肌梗死”。据报道，有多种原因可引起 Kounis 综合征。其中包括多种疾病、多种药物、食物和昆虫叮咬等。本文讨论了这种重要综合征的临床方面、诊断、发病机制、发生率和流行病学、相关情况和治疗管理。
