哮喘研究与随机对照试验：一个显著的现象。
Asthma research and randomized controlled trials: a remarkable phenomenon.
作者信息
Hafkamp-de Groen Esther, Raat Hein
机构信息
Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
出版信息
J Asthma. 2010 Nov;47(9):1063-4. doi: 10.1080/02770903.2010.517591.
BACKGROUND
Time trends in the number of publications of randomized controlled trials (RCTs) in asthma research have never been evaluated.
METHODS
A PubMed database scan was made to identify publications in asthma research per year since 1990 until 1 January 2010, using the term 'asthma'. The total number of publications was ascertained, as was the number when restricting the search strategy to RCTs only.
RESULTS
The total number of publications in asthma research increased from 2240 per year in 1990 to 5601 per year in 2009. The number of publications of RCTs in asthma research was 198 per year in 1990 and 233 per year in 2009.
DISCUSSION
The remarkable phenomenon of an almost unchanged number of publications of RCTs in asthma research per year in the period 1990-2009 may be explained by criticism to RCTs in asthma research.
CONCLUSION
Despite an increase in total publications of asthma research, time trends in the number of publications of RCTs in asthma research per year show an almost unchanged number in the period 1990-2009. Evidence-based medicine within the field of asthma still faces many challenges.
背景
哮喘研究中随机对照试验（RCT）的发表数量随时间的变化趋势从未被评估过。
方法
对PubMed数据库进行扫描，以识别自1990年至2010年1月1日每年哮喘研究方面的出版物，使用关键词“哮喘”。确定了出版物的总数，以及仅将搜索策略限制为随机对照试验时的数量。
结果
哮喘研究的出版物总数从1990年的每年2240篇增加到2009年的每年5601篇。哮喘研究中随机对照试验的发表数量在1990年为每年198篇，在2009年为每年233篇。
讨论
1990 - 2009年期间哮喘研究中随机对照试验每年发表数量几乎不变这一显著现象，可能是由于对哮喘研究中随机对照试验的批评所致。
结论
尽管哮喘研究的出版物总数有所增加，但1990 - 2009年期间哮喘研究中随机对照试验每年发表数量的时间趋势显示几乎没有变化。哮喘领域的循证医学仍面临许多挑战。
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