Department of Surgery, Fukuoka Higashi Medical Center, Koga, Japan.
Am J Surg. 2011 Feb;201(2):186-91. doi: 10.1016/j.amjsurg.2010.01.030. Epub 2010 Sep 15.
The significance of the Glasgow prognostic score (GPS), an inflammation-based prognostic score, as an indicator of aggressiveness in gastric carcinoma has not been investigated fully.
Two hundred thirty-two patients with gastric carcinoma were enrolled. Patients who had both an elevated C-reactive protein (>1.0 mg/dL) and hypoalbuminemia (<3.5 g/dL) were allocated a traditional GPS (TGPS) of 2. Patients who had one of these abnormal values were allocated a TGPS of 1, and patients who had neither were allocated a TGPS of 0.
There existed a significant difference between the survival of adjacent groups of patients when examined using the TGPS (P = .05 for TGPS 0 vs 1 and P = .006 for TGPS 1 vs 2). Multivariate analysis based on TGPS demonstrated that TGPS (P = .020) and tumor stage (P = .0007) proved to be independent prognostic indicators for worse prognosis.
The preoperative measurement of an inflammation-based prognostic score can demonstrate a strict stratification for the prognosis of patients with gastric carcinoma.
格拉斯哥预后评分（GPS）是一种基于炎症的预后评分，其作为胃癌侵袭性的指标尚未得到充分研究。
纳入 232 例胃癌患者。如果患者 C 反应蛋白升高（＞1.0mg/dL）且低蛋白血症（＜3.5g/dL），则分配传统 GPS（TGPS）2 分。如果患者只有其中一项异常，则分配 TGPS 1 分，如果两项均无异常，则分配 TGPS 0 分。
使用 TGPS 对相邻组患者的生存情况进行检查时，存在显著差异（TGPS 0 与 1 比较，P=0.05；TGPS 1 与 2 比较，P=0.006）。基于 TGPS 的多变量分析表明，TGPS（P=0.020）和肿瘤分期（P=0.0007）是预后不良的独立预后指标。
术前炎症预后评分的测量可以对胃癌患者的预后进行严格分层。
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