Faculdade de Engenharia Química, Departamento de Sistemas Químicos e Informática DESQ, Universidade Estadual de Campinas, Rua Zeferino Vaz, CEP 13081-970 Campinas, SP, Brazil.
J Colloid Interface Sci. 2010 Dec 1;352(1):107-13. doi: 10.1016/j.jcis.2010.08.051. Epub 2010 Aug 21.
Smart hollow microspheres composed of vinyled-chondroitin sulfate conjugates (CSπ) and magnetite nanoparticles were obtained by the intermediate of a multiple emulsion in absence of a surfactant, attributable to stabilizing properties of the CS. It was formed an oil-water multiple emulsion in which the CS played a role as an anionic stabilizer for magnetite nanoparticles via complexation. Iron oxides were bonded to the microspheres by the formation of a complex of Fe(3+) ions on the crystalline phase with oxygen atoms at the carboxyl groups without their magnetic properties being affected. The average crystal size of embedded magnetite nanoparticles was approximately 16.5nm, indicative of a good dispersion in microspheres. Furthermore, the introduction of iron oxides resulted in microspheres with a higher diameter and a narrower particle size distribution.
采用无表面活性剂的复乳法，通过中间产物得到了由乙烯基化硫酸软骨素共轭物（CSπ）和磁铁矿纳米粒子组成的智能中空微球。在这种复乳中，CS 通过与磁铁矿纳米粒子形成复合物，起到了阴离子稳定剂的作用。通过在结晶相中形成 Fe(3+) 离子与羧基氧原子的复合物，将氧化铁键合到微球上，而不会影响其磁性。嵌入的磁铁矿纳米粒子的平均晶体尺寸约为 16.5nm，表明在微球中有良好的分散性。此外，引入氧化铁会导致微球的直径增大，粒径分布变窄。
