5-HTTLPR 基因型调节青少年早期物质使用对风险性行为的影响。
5-HTTLPR status moderates the effect of early adolescent substance use on risky sexual behavior.
机构信息
Center for Family Research, University of Georgia, 1095 College Station Road, Athens, GA 30605-4527, USA.
出版信息
Health Psychol. 2010 Sep;29(5):471-6. doi: 10.1037/a0020594.
OBJECTIVE
A longitudinal, prospective design was used to investigate a moderation effect in the association between early adolescent substance use and risky sexual behavior 2 years later. A genetic vulnerability factor, a variable nucleotide repeat polymorphism (VNTR) in the promoter region of the serotonin transporter gene SLC6A4, known as 5-HTTLPR, was hypothesized to moderate the link between substance use at age 14 and risky sexual behavior at age 16. This VNTR has been associated with risk-taking behavior.
DESIGN
African American youths in rural Georgia (N = 185) provided 2 waves of data on their substance use and sexual behavior. Genetic data were obtained via saliva samples.
MAIN OUTCOME MEASURES
Substance use and sexual risk behavior were assessed using youth self-report items developed for this investigation.
RESULTS
Multiple regression analyses indicated that the presence of 1 or 2 copies of the short allele of the VNTR interacted with substance use to predict sexual behavior. Substance use had little effect on sexual behavior for youths without the short allele; this effect was greatly increased for youths with the short allele.
CONCLUSION
Genetic vulnerability affected the implications of early onset substance use for later sexual behavior.
目的
采用纵向前瞻性设计，研究青少年早期物质使用与 2 年后高危性行为之间的关联中的调节效应。一个遗传易损因素，即 5-羟色胺转运体基因 SLC6A4 启动子区域的可变核苷酸重复多态性（VNTR），被称为 5-HTTLPR，假设其调节物质使用在 14 岁和高危性行为在 16 岁之间的联系。该 VNTR 与冒险行为有关。
设计
来自佐治亚州农村的非裔美国青少年（N=185）提供了 2 波关于他们的物质使用和性行为的数据。遗传数据是通过唾液样本获得的。
主要观察指标
物质使用和性风险行为使用为这项调查开发的青少年自我报告项目进行评估。
结果
多元回归分析表明，VNTR 的短等位基因的 1 或 2 个拷贝的存在与物质使用相互作用，从而预测性行为。对于没有短等位基因的青少年来说，物质使用对性行为的影响很小；而对于携带短等位基因的青少年来说，这种影响大大增加。
结论
遗传脆弱性影响了早期物质使用对以后性行为的影响。
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