CEA/DSV/iRCM/SREIT/LRT BP 12, 91680 Bruyères le Châtel, France.
Health Phys. 2010 Oct;99(4):553-9. doi: 10.1097/HP.0b013e3181c1cccd.
The aim of this study is to propose a single modeling structure to describe both plutonium and americium decorporation by DTPA, which is based on hypotheses mostly validated by experimental data. Decorporation efficacy of extracellular retention depends on the concentration ratio of DTPA vs. actinides and varies in each compartment according to the amount of biological ligands and their affinity for actinides. By contrast, because the relatively long residence time of DTPA after its cell internalization and the stability of actinide-DTPA complexes, intracellular decorporation efficacy is mainly controlled by a DTPA/actinide ratio, which is specific to each retention compartment. Although the affinity of DTPA is much lower for americium than for plutonium, a larger decorporation of americium can be obtained, which is explained by different biological ligands and/or their affinity for the actinide. Altogether, these results show that the relative contribution of intra vs. extracellular decorporation varies depending on the actinide, the chemical form of radionuclides, the galenic formulation of DTPA, and the treatment schedule.
本研究旨在提出一种单一的建模结构来描述 DTPA 对钚和锕系元素的去除作用，该结构基于主要通过实验数据验证的假设。细胞外滞留的去除效果取决于 DTPA 与锕系元素的浓度比，并根据每个隔室中生物配体的数量及其对锕系元素的亲和力而变化。相比之下，由于 DTPA 在细胞内化后具有相对较长的停留时间以及锕系元素-DTPA 配合物的稳定性，细胞内的去除效果主要受每个保留隔室特有的 DTPA/锕系元素比值控制。尽管 DTPA 与锕系元素的亲和力比与钚的亲和力低得多，但可以获得更大的锕系元素去除效果，这可以通过不同的生物配体和/或它们对锕系元素的亲和力来解释。总之，这些结果表明，细胞内与细胞外去除的相对贡献取决于锕系元素、放射性核素的化学形式、DTPA 的赋形剂和治疗方案。
