Jacobsen B K, Lund E
Institute of Community Medicine, University of Tromsø, Norway.
Int J Epidemiol. 1990 Dec;19(4):967-70. doi: 10.1093/ije/19.4.967.
High social class has been linked to increased risk of breast cancer. The present study elaborates the associations between a frequently-used indicator of social class, length of education, and some reproductive factors associated with risk of breast cancer (age at menarche, the number of children, age at first pregnancy and use of oral contraceptives) in 8030 women in Tromsø, Norway. We found a weak negative association between level of education and age at menarche and a stronger negative association with parity. Women with high level of education tended to have their first pregnancy relatively late in life and more frequently reported ever use of oral contraceptives. These relationships support the notion that the difference in the incidence of breast cancer between women with high and low social class may be due to reproductive factors.
社会阶层较高与患乳腺癌风险增加有关。本研究阐述了社会阶层常用指标——受教育年限,与挪威特罗姆瑟8030名女性中一些与乳腺癌风险相关的生殖因素(初潮年龄、子女数量、首次怀孕年龄和口服避孕药使用情况)之间的关联。我们发现教育水平与初潮年龄之间存在微弱的负相关,与生育胎次之间存在更强的负相关。教育水平高的女性往往首次怀孕时间较晚,且更频繁地报告曾使用口服避孕药。这些关系支持了这样一种观点,即社会阶层高和低的女性之间乳腺癌发病率的差异可能归因于生殖因素。