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阻塞性睡眠呼吸暂停的外科治疗:标准技术与新兴技术

Surgical treatment of obstructive sleep apnea: standard and emerging techniques.

机构信息

Department of Otorhinolaryngology, Sleep Disorders Center, University Medicine Mannheim, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany.

出版信息

Curr Opin Pulm Med. 2010 Nov;16(6):552-8. doi: 10.1097/MCP.0b013e32833ef7ea.

Abstract

PURPOSE OF REVIEW

Patients with obstructive sleep apnea (OSA), as well as their physicians, seek alternative therapies to continuous positive airway pressure (CPAP) due to problems with CPAP adherence. A large variety of surgical options exist, and each intervention must be individually evaluated. The author performed a literature search concerning surgery for sleep apnea until May 2010. The studies were evaluated according to evidence-based medicine criteria.

RECENT FINDINGS

An increasing number of controlled and even randomized controlled trials are available. Minimally invasive surgery remains under debate due to the very limited efficacy versus very low morbidity. Uvulopalatopharyngoplasty is still the standard procedure for many patients with moderate OSA, whereas maxillomandibular advancement is as effective as CPAP in severe OSA. Multilevel surgery is reserved to secondary treatment after CPAP failure. Tonsillectomy and maxillomandibular advancement may be offered as a first-line treatment in certain patients. There is increasing evidence that upper airway surgery has a positive impact on arterial hypertension, markers of cardiovascular disease, insomnia, daytime symptoms, quality of life, and CPAP adherence.

SUMMARY

Patients who are nonadherent to CPAP must be thoroughly evaluated before choosing any of the available surgical options. Upper airway surgery may improve disease markers of OSA, if appropriately chosen and properly indicated and performed.

摘要

综述目的

阻塞性睡眠呼吸暂停(OSA)患者及其医生因持续气道正压通气(CPAP)治疗的依从性问题,寻求CPAP之外的替代疗法。目前存在多种手术选择,每种干预措施都必须单独评估。作者检索了截至2010年5月有关睡眠呼吸暂停手术的文献。这些研究依据循证医学标准进行评估。

最新发现

现有越来越多的对照试验甚至随机对照试验。由于疗效非常有限而发病率极低,微创手术仍存在争议。悬雍垂腭咽成形术仍是许多中度OSA患者的标准手术,而颌骨前移术在重度OSA中的疗效与CPAP相当。多级手术留作CPAP治疗失败后的二线治疗。扁桃体切除术和颌骨前移术可作为某些患者的一线治疗方法提供。越来越多的证据表明上气道手术对动脉高血压、心血管疾病标志物、失眠、日间症状、生活质量和CPAP依从性有积极影响。

总结

在选择任何可用的手术方案之前,必须对不依从CPAP的患者进行全面评估。如果选择得当、指征明确且实施得当,上气道手术可能改善OSA的疾病标志物。

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