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非前庭耳蜗颅神经神经鞘瘤。

Nonvestibulocochlear cranial nerve schwannomas.

机构信息

Departments of Neurology and Ophthalmology, SUNY Upstate Medical University, 90 Presidential Plaza, Syracuse, NY, 13202, USA,

出版信息

Curr Treat Options Neurol. 2010 Jan;12(1):37-42. doi: 10.1007/s11940-009-0053-1.

Abstract

Nonvestibulocochlear cranial nerve schwannomas traditionally have been managed by surgical excision. Although debulking surgery is still considered the first treatment option for larger tumors, stereotactic radiosurgery is now preferred for smaller tumors because of its high tumor control rate and low treatment-related morbidity. Furthermore, an initial period of radiologic and clinical observation following the diagnosis should be strongly considered for smaller tumors because some may not grow or may grow at a slow rate. Medical management of tumor-associated symptoms (when present) should not be ignored. Most importantly, the time has come to embark on the first randomized controlled trials comparing clinical and radiologic observation, surgery, and radiosurgery in the management of cranial nerve schwannomas.

摘要

传统上,非前庭耳蜗颅神经神经鞘瘤通过手术切除来治疗。虽然大部分肿瘤仍采用肿瘤切除术,但由于其较高的肿瘤控制率和较低的治疗相关发病率,立体定向放射外科现在更适用于较小的肿瘤。此外,对于较小的肿瘤,在诊断后应强烈考虑进行初始的影像学和临床观察,因为有些肿瘤可能不会生长或生长缓慢。对于与肿瘤相关的症状(如果存在)的药物治疗也不应忽视。最重要的是,现在是时候开展第一项随机对照试验了,以比较在颅神经鞘瘤的治疗中临床和影像学观察、手术和放射外科的效果。

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