肌成纤维细胞基质在鳞状上皮癌、口腔发育异常及角化过度中的存在及分布情况。
Myofibroblast stromal presence and distribution in squamous epithelial carcinomas, oral dysplasia and hyperkeratosis.
作者信息
Seifi Safora, Shafaei Shahryar, Shafigh Ensieh, Sahabi Seid Mehdi, Ghasemi Hamidreza
机构信息
Oral and Maxillofacial Pathology, Faculty of Dentistry, Cellular and Molecular Research Center - Babol University of Medical Sciences, Babol, Iran.
出版信息
Asian Pac J Cancer Prev. 2010;11(2):359-64.
PURPOSE
Stromal elements play a key role in growth and development of different neoplasms. Myofibroblasts are the major components and occur in stromal tissue during carcinogenesis processes. The purpose of this study was to review the frequency and the distribution pattern of myofibroblasts(αSMA-positive) in the stroma of squamous epithelial carcinoma and to compare values with those for with oral dysplasia and hyperkeratosis.
METHODS
we evaluated αSMA protein frequency in hyperkeratosis (N =18), oral epithelial dysplasia (N=18) and oral squamous cell carcinoma (N=18) using immunohistochemistry.
RESULTS
αSMA-positive expression was observed in 67% of OSCC tissue samples with network and spindle patterns, whereas it was seen in 22% with a focal pattern in dysplasia and in 6% with a scanty pattern in hyperkeratosis cases.
CONCLUSION
These findings suggest that an increase in number of myofibroblasts and change in their distribution pattern occurs during carcinogenesis which can be an expression of their role in tumor invasive characteristics.
目的
基质成分在不同肿瘤的生长和发展中起关键作用。肌成纤维细胞是主要成分，在致癌过程中出现在基质组织中。本研究的目的是回顾鳞状上皮癌基质中肌成纤维细胞（α平滑肌肌动蛋白阳性）的频率和分布模式，并将其值与口腔发育异常和角化过度的值进行比较。
方法
我们使用免疫组织化学评估了角化过度（N = 18）、口腔上皮发育异常（N = 18）和口腔鳞状细胞癌（N = 18）中α平滑肌肌动蛋白蛋白的频率。
结果
在67%的口腔鳞状细胞癌组织样本中观察到α平滑肌肌动蛋白阳性表达，呈网状和梭形模式，而在发育异常中22%呈局灶性模式，在角化过度病例中6%呈稀少模式。
结论
这些发现表明，在致癌过程中肌成纤维细胞数量增加且其分布模式发生变化，这可能是它们在肿瘤侵袭特征中作用的一种表现。
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