miRNA 结合位点多态性作为癌症风险的生物标志物。
MicroRNA binding site polymorphisms as biomarkers of cancer risk.
机构信息
Yale University School of Medicine, 15 York Street, New Haven, CT 06510 USA.
出版信息
Expert Rev Mol Diagn. 2010 Sep;10(6):817-29. doi: 10.1586/erm.10.59.
Abstract
MicroRNAs (miRNAs) are well established as global gene regulators and thus, slight alterations in miRNA levels as well as their ability to regulate their targets may cause important cellular changes leading to cancer risk. 3´ untranslated region (UTR) miRNA binding site single nucleotide polymorphisms (SNPs) have added another layer of possible genetic variation involved in the complex process of oncogenesis. Identifying these key genetically inherited effectors of miRNA functioning has improved our understanding of the complexity of disease. Interest in the field has grown rapidly in only the last 5 years, with several studies reporting on the role of 3´UTR binding site SNPs as genetic markers of increased cancer susceptibility, as well as biomarkers of cancer type, outcome and response to therapy. Currently, there are numerous known miRNA binding site SNPs associated with multiple cancer subtypes.
摘要
微 RNA（miRNA）是一种成熟的全局基因调控因子，因此 miRNA 水平的微小变化及其调控靶基因的能力可能会导致重要的细胞变化，从而增加癌症风险。3'非翻译区（UTR）miRNA 结合位点单核苷酸多态性（SNP）增加了另一种可能的遗传变异，参与了肿瘤发生的复杂过程。确定这些关键的 miRNA 功能遗传效应因子，提高了我们对疾病复杂性的理解。在过去的 5 年中，该领域的研究兴趣迅速增长，有几项研究报告了 3'UTR 结合位点 SNP 作为癌症易感性增加的遗传标志物，以及癌症类型、预后和对治疗反应的生物标志物的作用。目前，有许多已知的 miRNA 结合位点 SNP 与多种癌症亚型有关。
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