淀粉样β蛋白前体中半胱天冬酶切割位点的重要性。
Importance of the caspase cleavage site in amyloid-β protein precursor.
机构信息
Buck Institute for Age Research, Novato, CA 94945, USA.
出版信息
J Alzheimers Dis. 2010;22(1):57-63. doi: 10.3233/JAD-2010-100537.
Abstract
Reports from multiple laboratories have now been published analyzing the critical nature of the caspase cleavage site of amyloid-β protein precursor (AβPP) for cell death induction, synaptic loss, hippocampal atrophy, long-term potentiation, memory loss, neophobia, and other aspects of the Alzheimer's phenotype. Here we review the results and implications of these studies for the understanding of Alzheimer's disease pathophysiology and the potential development of therapeutics that target this site in AβPP.
摘要
现在已经有多个实验室发表报告，分析了淀粉样β蛋白前体（AβPP）半胱氨酸蛋白酶切割位点对于细胞死亡诱导、突触丧失、海马萎缩、长时程增强、记忆丧失、恐惧症和阿尔茨海默病表型的其他方面的重要性。在这里，我们回顾了这些研究的结果及其对阿尔茨海默病病理生理学的理解以及针对 AβPP 中该位点开发治疗方法的潜在意义。
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