钙蛋白酶 10 基因与喉癌：生存分析。
Calpain 10 gene and laryngeal cancer: a survival analysis.
机构信息
Servicio de Otorrinolaringología, Hospital Universitario Virgen del Rocío, Avda Manuel Siurot s/n, 41013 Sevilla, Spain.
出版信息
Head Neck. 2011 Jan;33(1):72-6. doi: 10.1002/hed.21404.
BACKGROUND
Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. Calpains are Ca2+-dependent cysteine proteases that modulate cellular function. A novel association between calpain 10 (CAPN10) haplotypes and laryngeal cancer has been found recently. Therefore, the goal of this study was to analyze the contribution of CAPN10 alleles to laryngeal cancer survival.
METHODS
Patients were recruited from southern Spain. Genotypes were determined using pyrosequencing technology. We analyzed CAPN10 UCSNP-44, UCSNP-43, UCSNP-19, and UCSNP-63 allelic distributions in 199 patients with unrelated laryngeal cancer. Survival curves were calculated from the date of the intervention to the date of death. Multivariate analyses were done using the Cox proportional risk model.
RESULTS
UCSNP-19, UCSNP-43, and UCSNP-44 were unrelated to survival in both univariate and multivariate analyses. However, for UCSNP-63 genotype 12 a significant relationship was observed in multivariate analysis (hazard ratio [HR] = 2.73; 95% confidence interval [CI], 1.21-6.20).
CONCLUSION
CAPN10 UCSNP-63 genotype 12 seems to be related with a worse prognosis in laryngeal cancer.
背景
喉癌是一种常见的上呼吸道癌症，其发展涉及不同的环境和遗传因素。钙蛋白酶是一种依赖 Ca2+的半胱氨酸蛋白酶，可调节细胞功能。最近发现钙蛋白酶 10（CAPN10）单倍型与喉癌之间存在新的关联。因此，本研究的目的是分析 CAPN10 等位基因对喉癌生存的影响。
方法
患者来自西班牙南部。使用焦磷酸测序技术确定基因型。我们分析了 199 例无关联的喉癌患者中 CAPN10 UCSNP-44、UCSNP-43、UCSNP-19 和 UCSNP-63 的等位基因分布。从干预日期到死亡日期计算生存曲线。使用 Cox 比例风险模型进行多变量分析。
结果
UCSNP-19、UCSNP-43 和 UCSNP-44 在单变量和多变量分析中均与生存无关。然而，对于 UCSNP-63 基因型 12，在多变量分析中观察到显著的相关性（风险比[HR]=2.73；95%置信区间[CI]，1.21-6.20）。
结论
CAPN10 UCSNP-63 基因型 12 似乎与喉癌的预后较差有关。
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