Department of Pathology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India.
Ann Diagn Pathol. 2010 Oct;14(5):317-20. doi: 10.1016/j.anndiagpath.2010.04.003. Epub 2010 Jun 25.
Biliary hamartomas or von-Meyenburg complexes form part of a spectrum of ductal plate malformation that includes polycystic liver disease, congenital hepatic fibrosis, and Caroli disease. These lesions are known to have neoplastic transformation. Development of intrahepatic cholangiocarcinoma is well described in these complexes. Rarely, hepatocellular carcinomas (HCCs) have been seen in association with bile duct hamartomas, however; it is not clear whether development of HCC is an epiphenomenon unrelated to the precursor lesion or biliary hamartomas may progress to liver cancers. We herein report 4 interesting cases of hepatitis C virus-, alcohol-, and nonalcoholic fatty liver disease-associated end-stage liver disease with coexisting HCC and multiple large von-Meyenburg complexes.
胆管错构瘤或 von-Meyenburg 复合体是胆管板畸形谱的一部分，包括多囊肝病、先天性肝纤维化和 Caroli 病。这些病变已知具有肿瘤转化。在这些复合物中，肝内胆管癌的发展已有很好的描述。然而，胆管错构瘤罕见地与肝细胞癌 (HCC) 相关；尚不清楚 HCC 的发展是否是与前体病变无关的伴随现象，还是胆管错构瘤可能进展为肝癌。本文报告了 4 例有趣的丙型肝炎病毒、酒精和非酒精性脂肪性肝病相关终末期肝病合并 HCC 和多个大的 von-Meyenburg 复合体的病例。
