Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
Vaccine. 2010 Nov 3;28(47):7507-13. doi: 10.1016/j.vaccine.2010.09.004. Epub 2010 Sep 17.
Rotarix™ was introduced into the Belgian market in 2006 and RotaTeq™ in 2007, quickly reaching more than 85% vaccine coverage of all newborns in Belgium. The incidence of rotavirus gastroenteritis has been monitored in the Gasthuisberg University Hospital (GUH), Belgium since 1986, and since 1999 the genotypes of circulating rotavirus strains have been determined. The average percentage of rotavirus positive cases out of all hospitalized gastro-enteritis cases tested (>95% of these cases are younger than 5 years old) at the GUH between 1986 and 2006 was 19.0%. This percentage dropped to 12.4%, 9.6% and 6.4% in the three seasons post vaccine introduction (2006-2009), which is a decline of 34.7%, 49.4% and 66.3% respectively. In addition the rotavirus season was found to be shortened and delayed. The prevalence of the G2 genotype sharply increased in the 2006-2007 rotavirus season compared to the previous seasons and remained high (30-40%) in the 2007-2008 and 2008-2009 seasons. Rotavirus vaccines have strongly reduced the number of children hospitalized due to a rotavirus infection at the GUH; it is however unclear if the predominance of G2 genotypes is related to the vaccine introduction, or if this is attributable to normal genotype fluctuations. Continued surveillance will be pivotal to answer this question in the future.
罗特律®于 2006 年进入比利时市场，罗特佳®于 2007 年进入市场，迅速为比利时 85%以上的新生儿提供了疫苗接种。自 1986 年以来，比利时哈瑟尔特大学医院（GUH）一直在监测轮状病毒胃肠炎的发病率，自 1999 年以来，一直在确定循环轮状病毒株的基因型。1986 年至 2006 年期间，GUH 所有住院胃肠炎病例中轮状病毒阳性病例的平均百分比（这些病例中 95%以上的年龄小于 5 岁）为 19.0%。在疫苗引入后的三个季节（2006-2009 年），这一比例分别下降到 12.4%、9.6%和 6.4%，分别下降了 34.7%、49.4%和 66.3%。此外，轮状病毒季节被发现缩短和延迟。与前几个季节相比，G2 基因型在 2006-2007 年轮状病毒季节的流行率急剧上升，并在 2007-2008 年和 2008-2009 年的季节中保持高位（30-40%）。轮状病毒疫苗大大减少了 GUH 因轮状病毒感染而住院的儿童人数；然而，G2 基因型的优势是否与疫苗接种有关，或者这是否归因于正常的基因型波动，目前尚不清楚。未来，持续监测将是回答这个问题的关键。
