腹膜后孤立性纤维瘤所致低血糖症与高分子量胰岛素样生长因子II相关
Retroperitoneal solitary fibrous tumor-induced hypoglycemia associated with high molecular weight insulin-like growth factor II.
作者信息
Yamakawa-Yokota Fumiko, Ozaki Nobuaki, Okajima Akiko, Nishio Hideki, Nagasaka Tetsuro, Oiso Yutaka
机构信息
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
出版信息
Clin Med Res. 2010 Dec;8(3-4):159-62. doi: 10.3121/cmr.2010.888. Epub 2010 Sep 17.
Abstract
A man, aged 65 years, presented with frequent episodes of hypoglycemia and unconsciousness. Hypoglycemia was accompanied by undetectable serum insulin and C-peptide levels and a high serum insulin-like growth factor (IGF)-II level. He was found to have a retroperitoneal solitary fibrous tumor. He underwent successful resection of the tumor and had no hypoglycemic episodes after the operation. Immunohistochemical analysis revealed positive immunostaining for IGF-II in tumor cells. The presence of the high-molecular-weight form of IGF-II in the patient's serum was confirmed by immunoblotting, which suggests that his hypoglycemia was due to an increase in the plasma level of IGF-II secreted by the tumor.
摘要
一名65岁男性，出现频繁低血糖发作和意识丧失。低血糖发作时血清胰岛素和C肽水平检测不到，而血清胰岛素样生长因子（IGF）-II水平升高。发现他患有腹膜后孤立性纤维瘤。他接受了肿瘤切除术，术后未再出现低血糖发作。免疫组化分析显示肿瘤细胞中IGF-II免疫染色呈阳性。免疫印迹证实患者血清中存在高分子量形式的IGF-II，这表明他的低血糖是由于肿瘤分泌的IGF-II血浆水平升高所致。
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本文引用的文献
1
[A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia].
Hinyokika Kiyo. 2009 Jul;55(7):395-9.
2
Retroperitoneal malignant solitary fibrous tumor of the small pelvis causing recurrent hypoglycemia by secretion of insulin-like growth factor 2.
Eur Urol. 2009 Mar;55(3):739-42. doi: 10.1016/j.eururo.2008.09.050. Epub 2008 Oct 1.
3
Primary solitary fibrous tumor (SFT) in the retroperitoneum.
Urol Oncol. 2008 May-Jun;26(3):254-9. doi: 10.1016/j.urolonc.2007.03.024. Epub 2008 Feb 20.
4
Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases.
Endocr Relat Cancer. 2007 Dec;14(4):979-93. doi: 10.1677/ERC-07-0161.
5
Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia.
J Hepatobiliary Pancreat Surg. 2007;14(6):595-9. doi: 10.1007/s00534-007-1210-0. Epub 2007 Nov 30.
6
Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia.
Growth Horm IGF Res. 2006 Aug;16(4):211-6. doi: 10.1016/j.ghir.2006.05.003. Epub 2006 Jul 24.
7
Hypoglycemia associated with big insulin-like growth factor II produced during development of malignant fibrous histiocytoma.
Endocr J. 2003 Dec;50(6):753-8. doi: 10.1507/endocrj.50.753.
8
Solitary fibrous tumors of the pleura.
Ann Thorac Surg. 2002 Jul;74(1):285-93. doi: 10.1016/s0003-4975(01)03374-4.
9
Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior.
Hum Pathol. 1999 Dec;30(12):1464-73. doi: 10.1016/s0046-8177(99)90169-7.
10
Serum high molecular weight form of insulin-like growth factor II from patients with non-islet cell tumor hypoglycemia is O-glycosylated.
J Clin Endocrinol Metab. 1998 Aug;83(8):2875-7. doi: 10.1210/jcem.83.8.5021.
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