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立体定向低电压 X 射线辐照治疗年龄相关性黄斑变性。

Stereotactic low-voltage x-ray irradiation for age-related macular degeneration.

机构信息

Department of Ophthalmology, Eye Institute at Stanford, Vitreoretinal Center, Stanford University School of Medicine, Palo Alto, CA 94303, USA.

出版信息

Br J Ophthalmol. 2011 Feb;95(2):185-8. doi: 10.1136/bjo.2009.163907. Epub 2010 Sep 18.

Abstract

The IRay stereotactic low-voltage x-ray irradiation treatment system for age-related macular degeneration consists of a low voltage x-ray tube, an eye tracking system, a robotically controlled delivery system, a coupling device to facilitate tracking and stabilisation, a graphical user interface and gating software. Low-voltage x-rays are delivered in a series of three spots to the macula in a non-invasive manner through the inferior pars plana. These beams are designed to overlap on the centre of the macula. Each beam delivers one-third of the total dose, such that the total macula dose is three times an individual beam's dose. The device is designed to run off standard domestic electrical power, and no special shielding is necessary for the room. This system has been validated in Monte Carlo simulations, human cadaver eye studies, pre-clinical animal studies and in a phase I clinical trial.

摘要

Iray 立体定向低电压 X 射线辐照治疗系统用于治疗年龄相关性黄斑变性,它由一个低电压 X 射线管、一个眼球跟踪系统、一个机器人控制的输送系统、一个便于跟踪和稳定的耦合装置、一个图形用户界面和门控软件组成。低电压 X 射线以非侵入的方式通过下平面玻璃体连续发射到黄斑区的三个点上。这些光束设计成在黄斑中心处重叠。每个光束输送总剂量的三分之一,使得黄斑总剂量是单个光束剂量的三倍。该设备设计为使用标准的家用电源,房间不需要特殊屏蔽。该系统已经通过蒙特卡罗模拟、人体尸体眼研究、临床前动物研究和 I 期临床试验进行了验证。

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